CAS 124665 09 0 D6 4R Cis 6 hydroxymethyl 2 2 dimethyl 1 3-dioxane-4-acetic acid

CAS No . : 124665-09-0 Rosuvastatin Intermediate

(4R-Cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester

Chemical Name : (4R-Cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester

CAS No. : 124665-09-0

Molecular Formula : C13H24O5

Short Code: D6

Usage: Intermediate for Rosuvastatin calcium

Description: Rosuvastatin Calcium is the active ingredient (API) of branded drug Crestor. It was innovated by the Japanese drug maker Shionogi and cooperated the marketing with AstraZeneca. Rosuvastatin Calcium is the new generation of statins drugs after Lovastatin, Simvastatin and Atorvastatin. It is a fully synthesized product and used to treat high cholesterol and to prevent cardiovascular disease. Some persons also call it super statin to express its good effect. The annual sales of Crestor exceed US dollars 6.6 Billion in 2014. The first generic version of Crestor will launch in US in 2016.

4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate 99.0% min CAS No. : 799842-06-1

is one of its intermediates. There are several synthesis routes to manufacture this intermediate but some routes are protected by the patents in some countries including Europe, USA and China. We strictly obey the laws and our commercial products are manufactured without infringing such patents. But anyway, the buyers should know the patent status by themselves. We promise to supply the real route of synthesis to the buyers. The buyers should take the risks of patent infringement by themselves.

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